In 2006, Paz Vega took a significant step in her career by working in Hollywood alongside director James L. Brooks, co-starring with Adam Sandler in "Spanglish." This role earned her the Best Breakthrough Actress award from the Phoenix Film Critics Society. Since then, she has collaborated with renowned directors such as Pedro Almodóvar, Frank Miller, Danis Tanovic, Oliver Parker, Michelle Placido, and the Taviani Brothers. She has shared the screen with international cinema icons like Scarlett Johansson, Diego Luna, Jason Clarke, Andy McDowell, Eva Méndez, Adrien Brody, Colin Farrell, and legendary actors including Rob Lowe, Christopher Lee, Christopher Walken, Antonio Banderas, Morgan Freeman, Nicole Kidman, and Sylvester Stallone, among others.

In 2023 Paz Vega, as she led the cast of "Kaleidoscope" alongside Giancarlo Esposito, Tati Gabrielle, Rufus Sewell, and Jai Courtney. This Netflix production, produced by Ridley Scott, has become a global success. Closing the year on a high note, Paz Vega concludes 2023 by representing Spain as the host of the Latin Grammys alongside Sebastián Yatra, Roselyn Sánchez, and Danna Paola.

The year 2024 commenced exceptionally for Paz Vega, with over 60 acting credits alongside international luminaries, Paz makes her directorial and screenwriting debut with "RITA" which will be release on 2024, showcasing her commitment and passion for the film industry and solidifying her status as a multidisciplinary artist eager to continue surprising audiences. Additionally, she ventures into new projects, taking on the lead role in the comedy "No puedo vivir sin ti" where she shares the screen with Argentine actor Adrián Suar, which has been released in Netflix. Furthermore, she participates in a new Netflix series, "1992", a thriller directed by Álex De la Iglesia, solidifying her versatility and distinguished career in the world of entertainment, 

In addition to her facet as an actress, Paz has become a style reference, grabbing covers and pages of magazines such as Esquire, Vogue, Vanidades, Neo2, Woman, Elle, Yo Dona, and Harpers Bazaar.

Paz Vega has more than 539k followers on her networks, with whom she shares moments of her professional life.